[phenixbb] Senior Scientist opportunity in Protein Engineering within Sanofi Biologics Research

yanfeng zhou yanfengzhou.pku at gmail.com
Fri Jun 7 10:40:17 PDT 2019

Hi all,

We have a new Senior Scientist opportunity in Protein Engineering within
Sanofi Biologics Research.  Please follow the link below for application




   *Senior Scientist- Framingham/MA*

   *Job Description*

   A highly motivated structural biologist is sought to join our structural
   biology team in Protein Engineering within Sanofi US Biologics Research
   department. We use leading edge crystallography, cryoEM, and computational
   modeling tools to support different project needs from Sanofi’s
   multi-targeting multi-modality research pipeline. Our structural biology
   team has a great track record of publications in the area of biologics
   characterization, antibody engineering and multi-specific antibodies.

   *Job role*
   - Work closely with experienced scientists in a dynamic and highly
      collaborative global environment.
      - Plan with project teams to address their questions of biologics
      candidate with customized structural biology tools.
      - Deliver high quality structural information of antibody antigen
      complex using crystallography, cryoEM, and HDX-MS as needed.
      - Provide structure based analysis and rational design with
      computational programs to optimize biologics candidate, including epitope
      analysis and comparison, structure-function relationship, developability
      risk mitigation, stability, humanization/simianization, and affinity

   *Basic qualifications*
   - Ph.D. in protein crystallography, cryoEM, or equivalent with less than
      5 years of postdoctoral or industrial experience.
      - Proven in-depth knowledge and expertise in protein structural
      biology and biochemistry demonstrated preferably through principal
      authorship in peer-reviewed publication(s).
      - Specifically, candidate must have extensive experience in protein
      construct optimization, protein purification, data collection
and structure
      determination either with crystallography or cryoEM with strong protein
      chemistry skills.
      - Expertise in common crystallography or cryoEM software and
      refinement at low resolution are required.

   *Preferred Qualifications*
   - Strong and consistent written and oral communication ability in
      professional settings.
      - Experience with biochemical biophysical assays/techniques (DLS,
      MALS, DSF, HPLC, AUC) and mass spectrometry.
      - Knowledge of antibody structures, experience with CRO or project
      management are also desirable.
      - Experience with developability prediction and engineering.
      - Familiarity with lab robotics and automation and other protein
      biophysical characterization techniques is preferred.
      - Programming skill with Python, Perl, MATLAB, etc is a plus.

   Sanofi Inc. and its U.S. affiliates are Equal Opportunity and
   Affirmative Action employers committed to a culturally diverse workforce.
   All qualified applicants will receive consideration for employment without
   regard to race; color; creed; religion; national origin; age; ancestry;
   nationality; marital, domestic partnership or civil union status; sex,
   gender, gender identity or expression; affectional or sexual orientation;
   disability; veteran or military status or liability for military status;
   domestic violence victim status; atypical cellular or blood trait; genetic
   information (including the refusal to submit to genetic testing) or any
   other characteristic protected by law.

   At Sanofi diversity and inclusion is foundational to how we operate and
   embedded in our Core Values. We recognize to truly tap into the richness
   diversity brings we must lead with inclusion and have a workplace where
   those differences can thrive and be leveraged to empower the lives of our
   colleagues, patients and customers. We respect and celebrate the diversity
   of our people, their backgrounds and experiences and provide equal
   opportunity for all.
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