[phenixbb] Registration open: Future of Fragments symposium - Diamond, 28/29 Nov 2016

Frank von Delft frank.vondelft at sgc.ox.ac.uk
Thu Sep 22 23:56:05 PDT 2016

Dear all

Registration is now open for the Future of Fragments symposium on 28/29 
November at Diamond Light Source, UK.


Places will be tight, so register early to give us time to gauge whether 
we must adapt plans.

Crystal-based fragment screening of novel protein targets linked to 
disease has truly come of age: Diamond's XChem facility has been 
operating a regular user program since 2015, with other synchrotrons 
soon to follow suit. A progression of user projects have confirmed the 
power of this approach to discover both diverse chemotypes and 
unexpected mechanisms of action, especially allosteric binders.

At the same time, the continued success in unearthing a rich array of 
fragment hits has now decisively shifted the bottleneck onto the 
question of how to translate hits into high potency leads. This 
challenge has highlighted the need for efficient and scalable 
methodologies in the areas of library design, label-free assays, 
computational compound design and the synthesis of complex lead molecules.

This symposium aims to highlight the opportunities that must be explored 
if routine fragment screening is to turn into routine lead discovery. 
The event will bring together speakers from diverse disciplines to help 
define the methodology, focus and goals for fragment screening in the 
coming years.

The four sessions will cover:  screening methodology;  computational 
methods;  new synthetic methods;  and automated chemistry.
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