[phenixbb] Post-doctoral position in Structural Biology

Dhirendra K Simanshu simanshu at gmail.com
Mon Jun 13 12:36:15 PDT 2016

A post-doctoral position (
structural biology) is available in the RAS initiative
​ ​
at Frederick National
Laboratory for Cancer Research (operated by Leidos Biomedical Research for

Please visit the link below for more details and instructions on how to

The structural biology group in the RAS initiative focuses on structural
analysis of KRAS mutants and biologically relevant KRAS activator/effector
complexes in support of drug discovery efforts and to further understand
the biochemistry of RAS proteins. We are looking for a highly motivated
post-doctoral fellow to join our group. Highly motivated candidates who
recently obtained a Ph.D. with a strong background in biochemistry,
biophysics and structural biology are encouraged to apply. This post-doc
will work closely with the protein production group and carry out
structural studies on oncogenic KRAS complexed with effectors, GAPs,
regulators and small molecules. We use X-ray crystallography, NMR,
molecular modeling, and other biophysical techniques for structural

The candidate will be expected to be able to participate in experimental
design and to independently conduct experiments in a priority-driven
environment. The candidate should have the ability to act both
independently and as a part of the RAS team in pursuit of specific research
goals and objectives. The structural biology group in the RAS initiative
works very closely with the biochemistry and biophysics group, and is well
equipped with crystallization robotics, in-house X-ray generator, and has
regular access to the synchrotron beamline at Argonne.


   - Possession of a doctoral degree from an accredited college/university
   according to the Council for Higher Education Accreditation (CHEA) in a
   field related to structural biology, biochemistry, biophysics or
   computational biology
   - Foreign degrees must be evaluated for U.S. equivalency
   - Demonstrated proficiency in protein biochemical and biophysical
   - Ability to act both independently and as a part of the RAS team in
   pursuit of specific research goals and objectives
   - Ability to conduct experiments and evaluate results independently
   - Experience in crystallization and structure determination of
   protein-ligand and protein-protein complexes


   - Experience working with small GTPases or RAS-related effector proteins
   and Knowledge of molecular dynamics simulations and protein-ligand docking.
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