[phenixbb] postdoctoral position MRC Laboratory of Molecular Biology

Roger Williams rlw at mrc-lmb.cam.ac.uk
Tue Jan 26 07:24:06 PST 2016

A three-year postdoctoral position is available with the group of Roger Williams at the MRC Laboratory of Molecular Biology in Cambridge, UK. 

The project, which is funded by Cancer Research UK is aimed at understanding structural mechanisms of regulation of the target of rapamycin complexes. Specifically to undertake research to investigate the structures and regulation of the mTORC1 complex assembled with its regulators on lysosomal membranes. The objective is to determine the structures of mTORC1 in complexes with its regulators and to understand how these complexes assemble on lysosomal membranes. Methods involved in the study include large scale mammalian cell culture, cryo-electron microscopy; X-ray crystallography; hydrogen-deuterium exchange mass spectrometry; biophysical measurements of assembly on membranes by confocal microscopy, flow cytometry and single-molecule fluorescence; and enzyme assays. 

The candidate should have a Ph.D. degree or due to complete doctoral studies within 6 months of applying. It is essential that the candidate has an enthusiasm for structural biology. Experience with electron microscopy, X-ray crystallography, mass spectrometry or large scale eukaryotic expression systems would be desirable, but a motivated candidate could learn any or all of these.

The MRC Laboratory of Molecular Biology is one of the birthplaces of modern molecular biology and has amazing support for all aspects of structural biology.

For full details, see the MRC link https://mrc.tal.net/vx/mobile-0/appcentre-ext/brand-3/candidate/so/pm/4/pl/1/opp/68-Postdoctoral-Scientist-PNAC-Dr-Roger-Williams-LMB-68/en-GB <https://mrc.tal.net/vx/mobile-0/appcentre-ext/brand-3/candidate/so/pm/4/pl/1/opp/68-Postdoctoral-Scientist-PNAC-Dr-Roger-Williams-LMB-68/en-GB>
 or contact Roger Williams: email rlw at mrc-lmb.cam.ac.uk <mailto:rlw at mrc-lmb.cam.ac.uk> or phone: +44 1223 267094

Dr. Roger Williams, FMedSci
rlw at mrc-lmb.cam.ac.uk <mailto:rlw at mrc-lmb.cam.ac.uk>
MRC Laboratory of Molecular Biology
Francis Crick Avenue
Cambridge Biomedical Campus
Cambridge CB2 0QH
Phone: +44 1223 267094
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